Sustained-release tablet of heavy CRS_2017 reduce methods: metformin hydrochloride

Large doses of the drug sustained-release skeleton (ER) formula usually tablet is bigger, may be for the patient acceptance and adherence to cause certain effect.This study aims to explore ease as a model drug contains 500 mg of metformin hydrochloride sustained-release tablet weight formula method, and keep the slow-release performance, reduce the tablet weight of actual choice.At the same time in line with the United States pharmacopoeia (USP) 39 degrees of various release testing standard to evaluate the drug release curve of different configuration option.